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KMID : 0921620110410030183
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Journal of Bacteriology and Virology
2011 Volume.41 No. 3 p.183 ~ p.187
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Protein Expression of the Human Norovirus Capsid Gene using the Baculovirus Expression System
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Jin Ji-Young
Park Chul-Jong
Park Seung-Won
Paik Soon-Young
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Abstract
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Human norovirus (HuNoV) is the major etiological agent of nonbacterial gastroenteritis worldwide. However, due to the absence of a rapid and sensitive diagnostic system, detection and monitoring have been limited. The HuNoV genome is composed of three open reading frames (ORFs). And major capsid protein, ORF2, is designated as a viral protein 1 (VP1). In this study, the baculovirus expression system was used for expression of the HuNoV capsid protein, VP1. Recombinant baculoviruses can be used as potent tools in HuNoV studies.
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KEYWORD
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Human norovirus, Baculovirus expression system
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